Reversal of end-stage heart failure in juvenile hemochromatosis with iron chelation therapy: a case report

Reversal of end-stage heart failure in juvenile hemochromatosis with iron chelation therapy: a case report

BACKGROUND Juvenile hemochromatosis is the most severe form of iron overloading phenotype. Although rare, it should be suspected in patients who present with hypogonadotropic hypogonadism, diabetes mellitus, or cardiomyopathy without a clear cause. CASE PRESENTATION A young Serbian male presenting with end-stage heart failure was referred for extracorporeal membrane oxygenation. An endomyocar...

Triple Drug Iron Chelation Therapy in Thalassemia Major; A Case Report

Regular packed cell transfusion in patients with thalassemia major leads to iron overload. Chelation therapy is one of the important aspects of thalassemia care as iron overload causes significant cardiac, hepatic, and endocrine dysfunction. We report a case of thalassemia major with severe iron overload causing cardiac and liver dysfunction who benefitted from triple drug chelation therapy. Tr...

Iron Chelation Therapy for Treatment of Cardiac Hemochromatosis

Hemochromatosis is a clinical syndrome caused by abnormal accumulation of iron in parenchymal organs leading to organ toxicity and dysfunction. Cardiac hemochromatosis is a cardiomyopathy due to primary iron-overload cardiomyopathy which causes congestive heart failure. Patients with cardiac hemochromatosis may be asymptomatic early in the disease. Once heart failure develops, there is rapid de...

CASE REPORT Reversal of severe pulmonary hypertension with â blockade in a patient with end stage left ventricular failure

A 52 year old man with severe chronic left ventricular failure (New York Heart Association class IV) was considered unsuitable for cardiac transplantation because of high and irreversible pulmonary vascular resistance (PVR). In an attempt to produce symptomatic improvement, metoprolol was cautiously introduced, initially at 6.25 mg twice daily. This was slowly increased to 50 mg twice daily ove...

Iron chelation therapy: you gotta have heart.